Gohil made her debut in acting with the serial Kitni Mast Hai Zindagi but became popular in Star One’s India Calling. She won the Zee TV's singing reality show Star Ya Rockstar. Gohil appeared in Star Plus' prime time show Gulaal. She was also seen in shows like 9X’s Remote Control and Star One’s Laughter Ke Phatke. She appeared in the Tamil romance film Leelai alongside actor Shiv Pandit, which was released in April 2012. Manasi has also appeared in a film called Leelai in the South and made her Hindi debut with Yeh Kaisi Life which premiered at the IFFI Festival in Goa. A trained classical singer, Gohil has provided vocals for films like Sanjay Leela Bansali's Devdas.