Mukul Harish made his first prominent role debut as a parallel lead in Star One's Annu Ki Ho Gayee Wah Bhai Wah as the negative character of Neil Mehra. He later replaced Kunal Kapoor in Sony's Meet Mila De Rabba. He did cameos in shows such as Bandini and Kitani Mohobbat Hai, and played the strong supporting positive character of Madhur in Agle Janam Mohe Bitiya Hi Kijo. Mukul landed the main lead character of Kartik in Zee TV's Mrs. Kaushik Ki Paanch Bahuein. Mukul Harish played a parallel lead role in Pavitra Rishta as Ranvijay.